Updated: 20 min 52 sec ago
A distinct gene module for T cell dysfunction distinct from activation in tumor-infiltrating T cells has now been discovered, thus paving the way for the development of new precision therapeutics.
People who receive a financial incentive to raise money for a charity they care about are actually less effective in soliciting donations, even when potential donors have no idea that incentives were involved, according to new findings. The research suggests that incentives may have this effect because they result in the fundraisers coming off as less sincere to the people they're trying to persuade.
Neutrophils are the superheroes of the body's immune system. Normally mild-mannered, they travel through the bloodstream until they reach an emergency situation, such as a cut or infection, where they switch into battle-mode to engulf and destroy foreign invaders. Neutrophils use ROS concentration to determine when to stop migrating and start killing, report scientists.
Is life better or worse after sticking your Fitbit in a drawer? Researchers surveyed hundreds of people who had abandoned self-tracking tools and found emotions ranged from guilt to indifference to relief that the tracking experience was over.
Researchers have discovered how a new epilepsy drug works, which may lead the way to even more effective and safer medications. Currently, the most commonly used anti-epilepsy drugs are ineffective for about 30 percent of people with seizure disorders.
Resistance to tamoxifen therapy in some estrogen receptor positive breast cancers may originate from in utero exposure to endocrine disrupting chemicals, research in animal studies suggests. This study provides a new path forward in human research as about half of the breast cancers treated with this common cancer therapy do not respond well, say researchers.
A new immunotherapy treatment has shown dramatic results in treating advanced pancreatic cancer, a deadly cancer that has seen little progress in treatment over the last 20 years.
A new molecular gel recipe is at the core of a prototype for a more accurate lead paint test. The new test is more clear and accurate than its counterparts. It consists of a vial that holds paint thinner and a sprinkling of certain salts that, when combined with the right concentration of lead, form a gel.
A researcher studying how the brain uses perception of the environment to guide action has a new understanding of the neural circuits responsible for transforming sensation into movement.
People synchronize what they remember and what they forget after sharing memories with one another, according to new research. The findings, have an applied scope: policymakers could use them to bust myths about certain topics, like how Zika virus is spread.
Two brain regions that are involved in creating panoramic memories have now been identified by neuroscientists. These brain regions, known as the OPA and RSC, help us to merge fleeting views of our surroundings into a seamless, 360-degree panorama.
Bacteria fight their competitors with molecular spear guns, the so-called Type VI secretion system. When firing this weapon they also unintentionally hit their own kind. However the related bacteria strains benefit from coming under fire. They recycle the protein components of the spear guns and use these to build their own weapons.
Scientists have implicated a type of stem cell in the calcification of blood vessels that is common in patients with chronic kidney disease. The research will guide future studies into ways to block minerals from building up inside blood vessels and exacerbating atherosclerosis, the hardening of the arteries.
Having a little bit of extra fat may help reduce the risk of developing diseases caused by toxic protein aggregation, such as Huntington's, Parkinson's and Alzheimer's. Scientists have discovered a new communication process between organelles inside the cell, including mitochondria, and shown how fat metabolism plays a central role in linking mitochondrial health to cytosolic protein homeostasis. Another study uncovers a new signaling pathway that may explain the peripheral wasting seen in Huntington's.
Researchers reporting in the journal Current Biology show catastrophic declines in wilderness areas around the world over the last 20 years.
A scanning technique for bones has been created that does not expose patients to X-ray radiation but provides exceptional 3-D images from which diagnoses and prognoses can be made. Their technique now provides information on bone quality as well as quantity.
During HIV infection, the virus mutates too rapidly for the immune system to combat, but some people produce antibodies that can recognize the virus even two years after infection. With an eye towards developing a vaccine, in four related papers describe a multi-step method for 'training' the immune system to produce these antibodies in genetically engineered mice.
Scientist have discovered that male animals, through their invisible chemical 'essence,' prime female animals for reproduction but with the unfortunate side effect of also hastening females' aging process. The females sense the two signals and respond by altering their physiology. These findings in roundworms, which echo those made in mammalian studies, could lead to therapies that delay puberty and prolong fertility in humans as well as combat aging.
When members of the BaYaka Pygmies living in the northern Republic of Congo get sick, they don't just go to the doctor for a prescription. Instead, they rely on their shared knowledge of medicinal plants to help them get well. Now, researchers have examined shared uses of those plants to understand how Pygmies have passed their extensive plant knowledge along from one person to the next.
Intracellular defects that lead to cells' failure to decommission faulty 'power packs' known as mitochondria cause nerve cells to die, triggering the symptoms of Parkinson's disease.