Epigenomic changes induced by pathogen infections, mediated by a transcription factor called ATF7, are the underlying mechanism of the memory of innate immunity, new research shows.
A strong physical gene interaction network has been discovered that is responsible for holding genes in a silencing grip during early development. In the same way that people can interact with others in close proximity, say within the same room, or others millions of miles apart, there are also short- and long-range interactions within the genome forming a three-dimensional configuration where different parts of the genome come into contact with each other. The research presents how key decision-making genes which specify the embryo's blueprint for subsequent development are physically clustered in the nucleus of embryonic stem cells and maintained in a silent state.
Thousands of new species are identified every year, and new and efficient methods are needed to document this diversity and to make information about new species available to other scientists and to the interested public. New research is literally adding a new dimension to the task.
The more hours young adults spend watching television each day, the greater the likelihood that they'll have a higher body mass index and bigger waist circumference, a 15-year analysis revealed.
People with hostile personality traits who watch more television than their peers may be at a greater risk for injury, potentially because they are more susceptible to the influence of television on violence and risk-taking behaviors, an analysis has discovered.
As part of a broad effort to study the environmental and societal effects of climate change, NASA has begun a multi-year field campaign to investigate ecological impacts of the rapidly changing climate in Alaska and northwestern Canada, such as the thawing of permafrost, wildfires and changes to wildlife habitats.
An anonymous reader writes: Early estimates suggest the 2016 U.S. presidential election will result in $5-10 billion in spending by candidates and organizations — much more than ever before. To support this, they need lots of contributions, and the tech industry is becoming a significant player. (Not as much as the financial industry, of course, but tech's influence is growing.) Re/Code breaks down which candidates are getting the most money from the tech sector so far. Right now, Senator Marco Rubio (R-FL) has gotten the most tech money by far — more than the rest of the field combined, thanks in large part to Larry Ellison. Jeb Bush, former governor of Florida, is a distant second, followed closely by former Secretary of State Hillary Clinton and Senator Bernie Sanders (I-VT). New Jersey governor Chris Christie and Senator Rand Paul (R-KY) are the only other candidates with significant tech contributions so far. Carly Fiorina, a tech industry veteran, has only managed about $13,000 in donations.
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On Sept. 27th, 2015, Earthlings will be treated to a skywatching event not seen seen 1982. The 'Supermoon' will also turn a reddish hue due to the moon passing directly behind the Earth, into its shadow.
dotarray writes: The boxed copy of Metal Gear Solid V: The Phantom Pain reportedly contains nothing but a Steam installer. That's right, even if you fork out real-world money for a physical copy of the game, you'll still have to download the whole thing from the internet. The game officially launches tomorrow. Early critical reviews are quite positive, though you should take that with a grain of salt until the game is more widely distributed. Game Informer says, "Unlike the linear design of previous entries, The Phantom Pain rarely assumes you have particular weapons and equipment, so the missions are brilliantly designed with multiple paths to success." The Washington Post notes, "The Phantom Pain’s openness feels like Kojima finally found a technical platform broad enough to make use of all of those tools and trusts players to build their own narrative drama from the way they choose to put these tools together for each mission." IGN has this criticism: "... where Phantom Pain’s gameplay systems are far richer and meatier than any the series has ever seen, its story feels insubstantial and woefully underdeveloped by comparison." Metal Gear Solid 5 is launching for PCs, current consoles, and previous-gen consoles; Digital Foundry thinks is likely to be the last true cross-generation AAA title.
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From 1952, DNA was sequenced, modified and extensively studied, but no technique was able to produce clear direct images of DNA. Now, researchers have developed a new technique to produce a direct image of the DNA helix and its inner structure.
Researchers have found that molecular machines can be easily manipulated using very small mechanical energy, taking advantage of the property that they aggregate on the surface of water.
Development of growth factor-free tissue adhesive porous films singularly capable of promoting angiogenesis
A group in Japan has developed tissue adhesive porous films that promote angiogenesis without using growth factors. This new technology may contribute to medical cost reduction making expensive growth factors-free.
There is a pathogen that is not new to Florida, however, new reports suggest that it is infecting the wild date palm. The good news is that it can be prevented most of the time by sterilizing pruning tools prior to pruning or by using a new pruning tool.
Fatal bleeding is rare with extended dual antiplatelet therapy, according to a secondary analysis of the DAPT Study. Bleeding-related mortality accounted for a minority of deaths in patients treated with dual antiplatelet therapy beyond one year.
Prasugrel associated with increased major bleeding in high-risk patients with stable coronary artery disease
Prasugrel-based dual antiplatelet therapy is associated with increased major bleeding after stent implantation for high-risk patients with stable coronary artery disease, according to a secondary analysis of the BASKET-PROVE II trial. Major bleedings were more pronounced in elderly and low-weight patients and raise concerns about the safety of prescriptions in these patients.
Life on an island isn't always easy. To make the most of the little there is to eat on many Greek islands, the digestive system of Balkan green lizards has evolved considerably compared to family members on the mainland. Surprisingly, many of these insect-eating lizards even have special valves that help to digest plants.
Ticagrelor administered in the ambulance reduces ischaemic events 24 hours after primary percutaneous coronary intervention (PCI), according to new findings.
Depressed patients have more frequent chest pain even in the absence of coronary artery disease, according to results. The findings suggest that pain and depression may share a common neurochemical pathway.
Marine energy has a great future potential according to the experts, but there is still a long way to go before it can be used on a large scale. A team of researchers has now developed a technique to forecast wave energy several hours in advance.
Cardiologists failed to identify more than half of basic and about 35 percent of advanced pre-recorded murmurs, but skills improved after a 90 minute training session, according to new research.