An entire class of proteins called transcription factors has largely been ignored by the pharmaceutical industry because it’s difficult to design and screen drugs against them. But a new study suggests that a key group of transcription factors are in fact ‘druggable,’ including several that could be targeted to treat cancer, metabolic disease, or autoimmune conditions.
How do you handle nuclear waste that will be radioactive for millions of years, keeping it from harming people and the environment? It isn’t easy, but a researcher has discovered ways to immobilize such waste – the offshoot of decades of nuclear weapons production – in glass and ceramics.
Treatment with the drug prazosin effectively reduces symptoms of posttraumatic stress disorder (PTSD) for many people, but about one third of patients don't respond to the treatment at all. Attempts to understand why people respond differently have fallen short. Now, a new study reports that soldiers with higher blood pressure before beginning prazosin treatment see better results from the medication.
The extracellular matrix (ECM) regulates all important cell functions and is an interesting biomaterial for scientists. An ECM has been created that contains artificial chemical groups which supports natural cell behavior outside the body. It can be applied as a stable coating on implants or be used in cell culture dishes.
The Northwest Passage is becoming navigable for longer periods of the year. Ship traffic, however, still bears hazardous risks. A German-Canadian research team wants to change that: it is conducting the preparatory work for a safe navigation through the icy waters.
Adding hydrogen to graphene could improve its future applicability in the semiconductor industry, when silicon leaves off. Researchers have recently gained further insight into this chemical reaction. These findings extend the knowledge of the fundamental chemistry of graphene and bring scientists perhaps closer to realizing new graphene-based materials.
Inadequate food intake and malnourishment in sick people is an area of concern for health policy and Public Health and one which impacts upon the social economics of countries with both high and low incomes.
Autism Spectrum Disorder is usually diagnosed in early childhood, but genetic detection of this brain disorder could mean more timely interventions that improve life for the patient and their carers. Research suggests that machine learning might be used to analyze genetic data that points to an ASD diagnosis before symptoms become obvious.
A new model shows how an electricity system mainly based on solar and wind works in all regions of the world. It shows the functioning of an electricity system that fulfils the targets set by the Paris agreement by using only renewable energy sources.
Cardiovascular disease, including heart disease and stroke, kills more than 800,000 Americans each year. We know that too much salt may contribute to high blood pressure and increased cardiovascular risk. According to a new study, American children are consuming sodium at levels that far exceed the daily recommended limit. Taste preferences for high sodium foods, formed as children, follow individuals into adulthood and put them at increased risk for developing cardiovascular problems later in life.
An anonymous reader quotes a report from Ars Technica: The Department of Justice today sued DirecTV and its owner, ATT, saying the satellite TV company colluded with competitors during contentious negotiations to broadcast Los Angeles Dodgers games. Dodgers games have been blacked out in much of Los Angeles because pay-TV providers have been unwilling to pay the price demanded by SportsNet LA, the Dodgers channel operated by the baseball franchise and Time Warner Cable. But the DOJ's antitrust division placed the blame for this situation on ATT and DirecTV. In a complaint filed in U.S. District Court in California, it alleges that DirecTV was a "ringleader" in a coordinated scheme with cable companies Cox and Charter, according to a DOJ announcement. ATT completed its purchase of DirecTV in July 2015, but the complaint covers a dispute that began before the merger and continues to this day. The Dodgers channel owners offered carriage licenses to the pay-TV companies in January 2014, but the channel is still not available on DirecTV, Cox, or ATT's wireline TV service. (Games are now available on Charter, which purchased Time Warner Cable this year.) The lawsuit "alleges that DirecTV unlawfully exchanged competitively-sensitive information with Cox, Charter, and ATT during the companies' negotiations for the right to telecast the Dodgers Channel," the DOJ announcement said. "Specifically, the complaint alleges that DirecTV and each of these competitors agreed to and did exchange non-public information about their companies' ongoing negotiations to telecast the Dodgers Channel, as well as their companies' future plans to carry -- or not carry -- the channel." The companies used this strategy "to obtain bargaining leverage and to reduce the risk that they would lose subscribers if they decided not to carry the channel but a competitor chose to do so." The information these companies learned from each other "through these unlawful agreements" was a major factor in their decision not to carry the Dodgers channel, the complaint said. ATT said it will fight the lawsuit and blamed Time Warner Cable for charging unreasonably high prices. The asking price was reportedly about $5 a month per subscriber regardless of how many people watch the games.