A special kind of small sulfur-rich proteins, the metallothioneins, have an extraordinarily large capability for binding heavy metals. An international team of scientists has now discovered that the marine common periwinkle, which is widely considered a delicacy, contains the largest version of the protein found yet, with one additional cadmium-binding domain and a one-third higher detoxification capacity. This feature may help the snail survive in heavy-metal-polluted environments.
Carbapenems are among the 'antibiotics of last resort' and can fight infections for which other drugs have long lost their effectiveness. However, even carbapenem-resistant pathogenic strains have emerged over the last decades.
The molecular causes of diseases such as Parkinson's need to be understood as a first step towards combating them. Chemists recently succeeded in analyzing what happens when selective mutations of the alpha-synuclein protein occur -- a protein that is closely linked to Parkinson's disease.
The fact that men are overrepresented in psoriasis registers and consume more psoriasis care have long led researchers to believe that the common skin disease disproportionately affects men. A unique study with 5,438 Swedish psoriasis patients now reveals that women have a statistically significant lower incidence of severe psoriasis compared to men.
Through experimental and computational tests, new research expands on the theory of virus surface hydrophobicity. By being slightly water-repellent, the outer layers of proteins in virus capsids affect how it interacts with cells and the environment. Understanding this more can improve vaccine production and virus detection.
Amazon.com on Thursday won a more than $1.5 billion tax dispute with the Internal Revenue Service over transactions involving a Luxembourg unit more than a decade ago. From a report: Judge Albert Lauber of the U.S. Tax Court rejected a variety of IRS arguments, and found that on several occasions the agency abused its discretion, or acted arbitrarily or capriciously. Amazon's ultimate tax liability from the decision was not immediately clear. The world's largest online retailer has said the case involved transactions in 2005 and 2006, and could boost its federal tax bill by $1.5 billion plus interest. It also said a loss could add "significant" tax liabilities in later years. Amazon made just $2.37 billion of profit in 2016, four times what it made in the four prior years combined, on revenue of $136 billion.
Astronaut Thomas Pesquet, who is taking a spacewalk with Shane Kimbrough today, will be adding lubricant to the Latching End Effector, the "hand" at the end of the Space Station Remote Manipulator System, otherwise known as Dextre.
An anonymous reader shares a VanityFair report: These days, it takes less than 60 seconds to know what the general consensus on a new movie is -- thanks to Rotten Tomatoes, the review aggregator site that designates a number score to each film based on critical and user reviews. Although this may be convenient for moviegoers not necessarily interested in burning $15 on a critically subpar film, it is certainly not convenient for those Hollywood directors, producers, backers, and stars who toiled to make said critically subpar film. In fact, the site may be "the worst thing that we have in today's movie culture" -- at least according to Brett Ratner, the Rush Hour director/producer who recently threw the financial weight of his RatPac Entertainment behind Batman v Superman: Dawn of Justice. Sure, the blockbuster made over $850 million worldwide in spite of negative reviews ... but just think of how much more it could have made had it not had a Rotten Tomatoes score of 27 percent! Last week, while speaking at the Sun Valley Film Festival, Ratner said, "The worst thing that we have in today's movie culture is Rotten Tomatoes. I think it's the destruction of our business."
According to NASA, Arctic sea ice appears to have reached on March 7 a record low wintertime maximum extent. On the opposite side of the planet, Antartica ice hit its lowest extent ever recorded by satellites (since satellites began measuring sea ice in 1979) on March 3 at the end of summer in the Southern Hemisphere. Science Daily reports: Total polar sea ice covered 6.26 million square miles (16.21 million square kilometers), which is 790,000 square miles (2 million square kilometers) less than the average global minimum extent for 1981-2010 -- the equivalent of having lost a chunk of sea ice larger than Mexico. The ice floating on top of the Arctic Ocean and surrounding seas shrinks in a seasonal cycle from mid-March until mid-September. As the Arctic temperatures drop in the autumn and winter, the ice cover grows again until it reaches its yearly maximum extent, typically in March. The ring of sea ice around the Antarctic continent behaves in a similar manner, with the calendar flipped: it usually reaches its maximum in September and its minimum in February. This winter, a combination of warmer-than-average temperatures, winds unfavorable to ice expansion, and a series of storms halted sea ice growth in the Arctic. This year's maximum extent, reached on March 7 at 5.57 million square miles (14.42 million square kilometers), is 37,000 square miles (97,00 square kilometers) below the previous record low, which occurred in 2015, and 471,000 square miles (1.22 million square kilometers) smaller than the average maximum extent for 1981-2010.
A new project aims to create an efficient, simple-to-manufacture oxygen-evolution catalyst that pairs well with semiconductors for advanced solar cells. The technique could lead to unique catalysts for other applications.
Researchers have developed a new algorithm that predicts when a user will leave a mobile game. This information is useful for game studios so that they can design strategies to maintain the player's interest.